Frank Fenner’s classic study of the pathogenesis of ectromelia (mousepox) viral infection
- Initial entry and replication at the local site of entry ±involvement of regional draining lymph nodes
- Primary viremia, leading to replication in liver and spleen
- Secondary viremia, with localization in the target organ(s)
- Replication in the target organ, leading to damage and symptoms
- Adaptive immune response, clearance of infected cells, elimination of the virus, repair of damage
Tags
Topic 8